WBB Research Institute Reports on CAR-T Cell Therapy, A New and Promising Advance in Cancer Treatment

Key Takeaways

  • WBB Securities, an investment bank specializing in biotechnology, medical devices and life sciences, successfully organized a webinar focusing on the potential of Chimeric Antigen Receptor T-Cells (CAR-T) therapy in the future of cancer treatment.
  • The webinar, organized by CEO Steve Brozak, DMH featured distinguished speakers and experts in the field of CAR-T Cell therapy who provided insights into the science behind the therapy, its clinical applications, and potential market growth.
  • The positive response to the event underscores WBB Securities' role in connecting investors with key developments in the healthcare industry and a growing interest in CAR-T Cell therapy among the investor community.

August 15, 2023 -- Clark, NJ -- The WBB Research Institute (WBBRI) recently hosted a two-part, 75-minute Demi-Colton Virtual Salon/Webinar on cell therapy and CAR-T, a breakthrough cancer treatment that modifies a patient’s own T-Cells to fight cancer. CAR-T and next generation cell therapies represent a considerable advance in oncology therapy.

Featured in the first part of the Webinar are two physician scientists on the frontier of this emerging medical technology - Doctors Helen Heslop and Malcolm Brenner from the Center for Cell and Gene Therapy at Baylor College of Medicine. They describe the current state of CAR-T therapy and ongoing research to enhance CAR-T and off-the-shelf cell therapy that can be used to treat any patient with any type of cancer.  

Segment One begins with an introduction by Steve Brozak, CEO of WBB Securities and founder of WBBRI, followed with a video presentation by Dr. Heslop, describing the current state of CAR-T cell technology, clinical applications, and potential markets. Following the video, Dr. Brenner describes an approach to using CAR-T therapy for treating solid tumors, saying we need “an approach that deals with a tumor holistically, and one of the ways it might be possible to do that is by focusing not so much on the proteins that those tumors express but also on the whole tumor glycan (matrix).”

During the second segment of the Webinar, the CEOs of two biotechnology companies describe the latest developments in cell therapy treatments. Dr. Juan Vera describes how Marker Therapeutics (NASDAQ: MRKR) is working to advance novel T-Cell therapies for blood cancers and solid tumors, and Dr. Mark Frohlich of Indapta Therapeutics, describes his company’s efforts to develop an off-the-shelf universal cell therapy to treat cancer. 

During this segment, Dr. Vera remarked on efforts to treat patients whose tumors are now resistant to CAR-T therapy. He said, “We envision that Marker’s multiple tumor-associated antigen (multiTAA) targeted therapy will be superior to treatment approaches targeting a single antigen, such as CAR-T cells.” 

Doctor Frohlich spoke about another cell-based anti-cancer agent that has demonstrated high efficacy -- natural killer cells or NK cells. He said, “Our highly potent g-NK cells offer the potential for a new treatment for patients that is effective, safer, has a lower cost of goods, and can democratize access to these transformative therapies.” 

Full recording is accessible through the link below:

https://virtualsalon.demy-colton.com/2023/07/13/car-t-cell-past-present-and-future/



WBB Securities
The WBB Research Institute is a research organization, founded by WBB Securities. The Institute focuses on emerging critical issues in healthcare that threaten to have profound impact. WBB Securities is a leading Investment Management, Investment Banking, and Equity Research firm focused on the life sciences. WBB Securities is registered with the SEC as a broker-dealer, a FINRA member firm, and a Registered Investment Advisor with a proprietary trading desk. The firm is comprised of a nationwide team of respected senior investment and research professionals serving institutional and high-net-worth clients.

Demy-Colton
Demy Colton is a leader in biotech and life science events, with over 20 years of experience connecting leaders of innovative biotech companies with key stakeholders, investors, and advisors, we create ideal environments to examine and address opportunities and challenges in today’s biotech industry.

Key Takeaways

  • WBB Securities, an investment bank specializing in biotechnology, medical devices and life sciences, successfully organized a webinar focusing on the potential of Chimeric Antigen Receptor T-Cells (CAR-T) therapy in the future of cancer treatment.
  • The webinar, organized by CEO Steve Brozak, DMH featured distinguished speakers and experts in the field of CAR-T Cell therapy who provided insights into the science behind the therapy, its clinical applications, and potential market growth.
  • The positive response to the event underscores WBB Securities' role in connecting investors with key developments in the healthcare industry and a growing interest in CAR-T Cell therapy among the investor community.

Media Gallery

Related Bios

Malcolm K Brenner, M.D., Ph.D
Baylor College of Medicine
Dr. Brenner's primary research interest is the use of gene transfer to augment the immune response to human tumors, using vaccines and adoptive transfer of genetically modified T cells.

In neuroblastoma, Dr. Brenner and co-investigators have shown that T cells expressing a chimeric antigen receptor (CAR) for a surface marker (GD2) on neuroblastoma cells can produce tumor responses in more than half the patients with refractory or relapsed disease leading to complete remission in 3/11 patients. His Center is also studying the benefits of T cells modified with CARs directed to other tumor antigens on hematological malignancies and solid tumors including Hodgkin Disease and Glioblastoma multiforme and initial clinical results are promising. Efforts are being made to further increase the effectiveness of these CAR-T cells by incorporating genes that enhance T cell growth and survival and that render the T cells resistant to the inhibitory effects of many human tumors.

To enhance the safety of genetically modified T cells, Dr. Brenner and colleagues have implemented an inducible caspase system that will rapidly cause apoptosis of T cells within minutes of administration of a small molecule dimerizing drug, allowing adverse effects from the T cells to be reversed. Initial clinical trials showed significant activity, and the approach is now being broadened to other novel T cell therapeutics.

Dr. Brenner’s group combines these adoptive transfer strategies with immunization against the tumors to produce synergistic benefits and clinical studies in chronic lymphocytic leukemia have recently begun.

Finally, in collaboration with the laboratories of Drs. Rooney, Heslop and Bollard, Dr. Brenner is continuing to study the use of gene modified cytotoxic T lymphocytes to prevent and treat the Epstein Barr virus associated malignancies, immunoblastic lymphoma, Hodgkin disease, and nasopharyngeal cancer (NPC). By transducing dendritic cells with EBV antigens, we are able to generate potent immune responses against the weak EBV latency antigens expressed in Hodgkin disease and NPC. Studies in 23 patients with relapsed or refractory EBV-positive Hodgkin and Non-Hodgkin lymphoma patients have produced complete responses in more than half. The potential to increase the effectiveness of the T-cells in vivo using monoclonal antibodies directed to immunological checkpoints is now being evaluated in clinical trials.
View Full Bio>>
Steve Brozak, DMH
Managing Partner & President, WBB Securities
Steve Brozak is the Managing Partner and President of WBB Securities. Before co-founding WBB Securities, Dr. Brozak held various positions in finance at several prominent Wall Street firms including Alex. Brown & Sons, Cowen & Company, Dean Witter, and Salomon Brothers.

As the firm’s Senior Equity Analyst, Dr. Brozak is an award winning analyst whose research has been singled out from his peers for accuracy and performance year after year by the financial industry’s most highly regarded rankings organizations. His research is currently monitored by the Bloomberg, StarMine and FactSet platforms. Most recently in 2013, Dr. Brozak was selected as a top analyst in the pharmaceuticals sector by the StarMine/Financial Times Industry Analyst Awards system. The Wall Street Journal distinguished Dr. Brozak as its Best on the Street Medical Equipment and Supplies financial analyst in its 19th Annual Best on the Street Survey. In 2010, Dr. Brozak received the StarMine Thompson Reuters/Financial Times Best Brokerage Analyst award in the Biotechnology space.

With a 30-year track record in sales, banking and analysis in life sciences, Dr. Brozak is a highly sought after media commentator on the life sciences sector by prominent news agencies on the web, television, and in print media. As a speaker, Dr. Brozak is invited to address major institutional audiences at numerous industry conferences and summits to share his ideas and expertise in identifying trends in the healthcare. Dr. Brozak is a published author in multiple scientific journals such as Nature, The British Medical Journal, and Brain Stimulation. He is also a contributor to Forbes and ABC News where he expresses his views about healthcare.

Dr. Brozak served in the United States Marine Corps retiring as a Lieutenant Colonel and in retirement served on the Secretary of the Navy’s Navy and Marine Corps Retiree Council, where he focused on healthcare, benefits and other veteran issues. Dr. Brozak received his BA and MBA from Columbia University, and his Doctorate in Medical Humanities (DMH) from Drew University. Dr. Brozak’s doctoral focus was on the U.S. healthcare system. Dr. Brozak holds FINRA licenses 3, 7, 8, 24, 63, 65, 79, 86, 87 and 99.
View Full Bio>>
Helen Heslop, MD, DSc (Hon)
Chair, Professor of Medicine and Pediatrics at Baylor College of Medicine, and the Director of the Center for Cell and Gene Therapy at Baylor College of Medicine
Dr. Heslop is Dan L Duncan Chair, Professor of Medicine and Pediatrics at Baylor College of Medicine, and the Director of the Center for Cell and Gene Therapy at Baylor College of Medicine, Houston Methodist Hospital and Texas Children’s Hospital. She is also the Interim Director of the Dan L. Duncan Cancer Comprehensive Center at Baylor College of Medicine. She is a physician scientist engaged in translational research focusing on adoptive immunotherapy with gene-modified effector cells, to improve hemopoietic stem cell transplantation and cancer therapy. An additional focus in reconstituting antiviral immunity post-transplant. She has extensive experience in developing and conducting transplant studies and cell and gene therapy studies and currently serves as sponsor for over 20 Investigational New Drug applications for cell therapy products with the FDA. She serves as Principal Investigator on several peer-reviewed research programs, including an LLS Specialized Center of Research (SCOR) award on Immunotherapy for Hematologic Malignancies.
View Full Bio>>
Mark W. Frohlich, MD
CEO at Indapta Therapeutics
Frohlich has more than 25 years of experience developing cellular immunotherapies to treat cancer. He previously served as executive vice president of portfolio strategy at Juno Therapeutics, which developed the FDA-approved CAR T-cell therapy Breyanzi for large B-cell lymphoma, until the company was sold to Celgene, now part of Bristol Myers Squibb.

Before Juno, Frohlich was chief medical officer and executive vice president at Dendreon Corporation, a pioneer in the development of cellular immunotherapy. At Dendreon, he led the clinical team responsible for the development and U.S. and European regulatory approval of Provenge, one of the first commercially available cancer immunotherapies.
View Full Bio>>
Juan F. Vera, M.D.
CEO at Marker Therapeutics
For the past 19 years, Dr. Vera has worked extensively on developing novel T cell therapies for clinical applications and has an extensive expertise in performing research in the field of adoptive T cell therapy. Dr. Vera has made several contributions in the field, specifically in the areas of developing and streamlining therapeutic candidates from the research bench to the clinic and from academia to industry.

Dr. Vera is a co-founder of Marker Therapeutics and AlloVir, and he has previously collaborated with Celgene and Bluebird Bio in developing novel CAR T cell therapies.

Prior to his appointment as CEO, Dr. Vera served as the Chief Operating Officer and Chief Scientific Officer of Marker Therapeutics. Before joining Marker, Dr. Vera was Associate Professor in the Department of Medicine, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston. He is a co-investigator on several clinical trials for T cell therapy in both infectious disease and cancer. Dr. Vera has published more than 30 articles and is a named inventor on 13 published patents.

In recognition of his work, Dr. Vera has received several prestigious awards including the Idea Development Award from the Department of Defense and Mentored Research Scholar Award from the American Cancer Society. Dr. Vera attained his M.D. from the University El Bosque in Bogota, Colombia.
View Full Bio>>
Querida Anderson
Managing Editor
Querida Anderson is the managing editor for Fierce Biotech, Medtech, Pharma and Healthcare. She oversees the group’s news, analysis and special reports as well as ‘The Top Line’ and ‘Podnosis’ podcasts. Before joining Fierce in June 2021, she was the editor in chief of GlobalData’s investigative pharma news team, formerly known as BioPharm Insight when it was owned by the Financial Times Group and subsequently BC Partners. Prior to that, she was the managing online editor at Genetic Engineering & Biotechnology News. Querida has also produced science news stories and documentaries for various networks like ABC, NBC, The Discovery Channel and National Geographic and has a Master’s in Science Journalism.
View Full Bio>>

Video Gallery

Video presentation by Dr. Helen Heslop, describing the current state of CAR-T cell technology
Download

Quotes

“
We need an approach that deals with a tumor holistically, and one of the ways it might be possible to do that is by focusing not so much on the pro...
Malcolm K Brenner, M.D., Ph.D — Baylor College of Medicine

Contacts

Henry Bassman
hbassman@wbbsec.com
9085229212